Journal: Cell metabolism
Article Title: Genetic analysis reveals AMPK is required to support tumor growth in murine Kras-dependent lung cancer models
doi: 10.1016/j.cmet.2018.10.005
Figure Lengend Snippet: (A) The 230 complete tumors within the Lung Adenocarcinoma TCGA dataset (TCGA, Provisional, 522 samples) were queried for alterations in mRNA levels of any of the 16 AMPK-dependent lysosomal lung cancer gene signature genes defined in Figure 3I. The RNA-seq z-score cut-off was set at +/− 2. Patient samples were divided into two groups; those with modulation of mRNA levels of lysosomal gene signature genes, termed “altered,” or those without major mRNA alterations in any of these genes, termed “unaltered.” Heatmap illustrates mRNA expression of each gene across all patient samples.
Article Snippet: DATA AND SOFTWARE AVAILABILITY Raw RNA sequencing data files have been deposited at Mendeley ( data.mendeley.com ).
Techniques: RNA Sequencing, Expressing